Pentapeptide-2

INCI: Pentapeptide-2 | Function: Skin Conditioning | Type: Peptide (Signal)

What Is Pentapeptide-2?

Pentapeptide-2 is a synthetic signal peptide of five amino acids designed to target specific cellular receptors for skin repair and rejuvenation. It functions as a biomimetic messenger that activates dermal fibroblasts to increase production of collagen, elastin, and glycosaminoglycans. Used in advanced anti-aging and post-procedure recovery formulations.

Key Skin Benefits

+ ECM regeneration — stimulates collagen and elastin synthesis
+ Dermal remodeling — improves skin architecture over time
+ Hydration support — boosts GAG production for water retention
+ Post-procedure recovery — accelerates healing after treatments

Pros

+ High specificity — designed for targeted receptor binding
+ Clinically relevant concentrations at ppm levels
+ Compatible with most anti-aging actives
+ No irritation or sensitization at use levels

Cons

− Premium pricing — specialized synthesis
− Limited published independent research
− Stability varies — may require cold processing
− Patent-protected sequences limit supplier options

Specifications

Property	Value
Usage Areas	Face, Eye, Body
Product Type	Leave-On
Source	Synthetic
Natural Level	Synthetic

Safety Ratings

Metric	Rating
Skin Sensitivity	0/5
Comedogenic Rating	0/5
EWG Score	1/10

Regional Regulatory Limits

Region	Leave-on %	Rinse-off %	Status
EU (CosIng)	No limit	No limit	Allowed
US (CIR/FDA)	No limit	No limit	Allowed
Japan (MHLW)	No limit	No limit	Allowed
ASEAN	No limit	No limit	Allowed
China (NMPA)	No limit	No limit	Allowed

Typical Usage % by Product Type

Product Type	Typical %
Anti-aging Serums	0.0005–0.005%
Recovery Creams	0.001–0.005%
Eye Treatments	0.0005–0.002%

References

CosIng Database — Pentapeptide-2. https://ec.europa.eu/growth/tools-databases/cosing/
Fields K et al (2009) — Bioactive peptides: signaling the future. PMID: 19941673
EWG Skin Deep — Pentapeptide-2. https://www.ewg.org/skindeep/

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