PERFLUOROCAPRYLYL BROMIDE
INCI: PERFLUOROCAPRYLYL BROMIDE | Function: Solvent, Oxygen Carrier | Type: Perfluorocarbon
What Is PERFLUOROCAPRYLYL BROMIDE?
Perfluorocaprylyl Bromide (全氟辛基溴, CAS 423-55-2) 是一种全氟化碳 (perfluorocarbon, PFC) 化合物。在医疗领域用作氧气载体 (oxygen carrier) 和造影剂。在化妆品中极少使用，主要作为特殊溶剂或氧气输送成分 (oxygen delivery)，用于高端伤口护理和氧疗类护肤品中，但市售产品中极罕见。
Key Skin Benefits
- + Oxygen Transport — 高溶氧量，理论上有助于组织氧合 (tissue oxygenation) 但缺乏化妆品临床证据
- + Inert & Non-reactive — 化学性质极度稳定，不与配方中其他成分反应
Pros
- + Extremely inert — no chemical reactivity with other formula ingredients
- + High gas solubility — used in medical oxygen therapeutics (not cosmetic)
Cons
- − PFAS compound — persistent environmental pollutant, EU proposing ban
- − Minimal cosmetic safety data — no CIR assessment for topical use
- − Bioaccumulative — accumulates in human tissue and environment
- − No proven cosmetic benefit — oxygen delivery claims lack robust evidence
- − Increasing regulatory restrictions worldwide on perfluorocarbons in cosmetics
Specifications
| Property | Value |
|---|
| Usage Areas | Body |
| Product Type | Leave-On |
| Source | Synthetic |
| Natural Level | Synthetic |
Safety Ratings
| Metric | Rating |
|---|
| Skin Sensitivity | 3/5 |
| Comedogenic Rating | 0/5 |
| EWG Score | 5/10 |
Regional Regulatory Limits
| Region | Leave-on % | Rinse-off % | Status |
|---|
| EU (CosIng) | Restricted | Restricted | Under PFAS restriction review |
| US (CIR/FDA) | No limit | No limit | Allowed — minimal cosmetic use |
| Japan (MHLW) | No limit | No limit | Not commonly used |
| ASEAN | No limit | No limit | Not commonly used |
| China (NMPA) | Not listed | Not listed | Rarely used |
Typical Usage % by Product Type
| Product Type | Typical % |
|---|
| Oxygen Facial Sprays (rare) | 0.1–1% |
| Wound Care Products (medical) | 5–20% |
References
- CosIng Database — Perfluorocaprylyl Bromide. https://ec.europa.eu/growth/tools-databases/cosing/
- PubMed — Riess JG (2001) Oxygen carriers (blood substitutes). PMID: 11222068
- ECHA (2023) — Annex XV PFAS restriction. https://echa.europa.eu/
- EWG Skin Deep — Perfluorocaprylyl Bromide. https://www.ewg.org/skindeep/