Phenacetin
Also known as: Phenacetin (banned analgesic)
INCI: Phenacetin | Function: BANNED — Do Not Use | Type: Banned substance (analgesic)
What Is Phenacetin?
Phenacetin 是一种已被全球多国禁止使用的镇痛解热药物。因明确致癌性 (carcinogenic) 和肾毒性 (nephrotoxic), 自 1983 年起被 FDA 撤回, 1987 年 IARC 将其列为 Group 1 人类致癌物。此成分在任何合法化妆品中均不应出现。在 NPRA 成分列表中出现仅作为禁限用物质的参考登记。
Key Skin Benefits
- + None — this ingredient is banned and carcinogenic
Pros
- + None — banned substance
Cons
- − BANNED in all cosmetics globally — IARC Group 1 carcinogen
- − Causes kidney damage (analgesic nephropathy)
- − Linked to urinary tract cancers
- − Withdrawn from pharmaceutical use since 1983
Specifications
| Property | Value |
|---|
| Usage Areas | N/A |
| Product Type | N/A |
| Source | Synthetic |
| Natural Level | Synthetic |
Safety Ratings
| Metric | Rating |
|---|
| Skin Sensitivity | BANNED |
| Comedogenic Rating | BANNED |
| EWG Score | 10/10 (BANNED) |
Regional Regulatory Limits
| Region | Leave-on % | Rinse-off % | Status |
|---|
| EU (CosIng) | BANNED | BANNED | Prohibited in cosmetics — Annex II |
| US (FDA) | BANNED | BANNED | Withdrawn 1983 — carcinogenic |
| Japan (MHLW) | BANNED | BANNED | Prohibited |
| ASEAN | BANNED | BANNED | Prohibited — Annex II |
| China (NMPA) | BANNED | BANNED | Prohibited |
Typical Usage % by Product Type
| Product Type | Typical % |
|---|
| Not used in cosmetics | N/A — banned |
References
- IARC Monographs — Phenacetin (Group 1). https://monographs.iarc.who.int/
- FDA — Withdrawn drug products list (1983). https://www.fda.gov/
- EU CosIng — Annex II prohibited substances. https://ec.europa.eu/growth/tools-databases/cosing/